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The E3 ubiquitin ligase CTRIP controls clock levels and period oscillations in Drosophila

Additionally, BDNF increases could represent a pathophysiological response to neurotoxic effects of cocaine

Supporting this interpretation, a previous clinical study reported that individuals carrying SNPs associated with reduced GLUT2 expression exhibit greater responsiveness to metformin, further suggesting that decreased intestinal glucose absorption mediated by reduced expression of glucose transporters such as GLUT2 may play an important role in enhancing overall glucose homeostasis after metformin administration 52

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