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Current guidelines from the European Society of Cardiology and American Diabetes Association strongly endorse GLP-1 receptor agonists with proven cardiovascular benefit for patients with established atherosclerotic cardiovascular disease

The art of tissue-specific and disease-specific dosing may emerge in the not-too-distant future: Rather than using the current pharmacologic doses of GLP-1s to soak receptors throughout the body, we may learn how to apply much more tailored brush strokes to effectively treat, say, dementia or rheumatoid arthritis

Pending those results, some authors in the literature have advocated for early prophylactic intervention for levels of retinopathy that approach current evidence-based treatment thresholds

Ozempic/Mounjaro/Wegovy interact with a region of the brain called the mesolimbic system, which overlaps with the brain processes that dictate addictive behaviours