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Palacios G, Muro A, Verd E, Pumarola M, Vela JM

While safe at therapeutic doses of up to 4 g per day for adults, APAP overdoses, either accidental or intentional, are one of the leading causes of acute liver failure in the United States [33]

With concurrent downregulation of ferroportin (FPN) and iron-regulating proteins (IRP1/2), M1-polarized macrophages show increased hepcidin (Hamp) and ferritin heavy/light chains (FTH/FTL) relative to their M2 counterparts ( Usually, iron abundance favors M1 polarization