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Abbreviations AC Adenylate cyclase ATP Denosine triphosphate BAT Brown adipose tissue BCAAs Branched-chain amino acids BCKA Branched-chain keto acids BMI Body mass index cAMP Cyclic adenosine monophosphate CNS Central nervous system CREB CAMP response element-binding DIO Diet-induced obesity DPP- 4 Dipeptidyl peptidase- 4 EGFR Epidermal growth factor receptor EPACs Exchange proteins directly activated by Camp Foxo1 Nuclear transcription factor GIP Glucose-dependent insulinotropic polypeptide GIPRAb GIP receptor antagonist antibody GPCRs G-protein-coupled receptors GTP Guanine triphosphate HbA1c Glycated haemoglobin HSL Hormone-sensitive lipase ICV Intracerebroventricular IR Insulin resistance LAGIPRA Long-acting GIP receptor agonist MAPK Mitogen activated protein kinase MASLD Metabolically associated steatotic liver disease PI3 K-PKB/Akt Phosphoinositide- 3-kinaseprotein kinase B/Akt PKA Protein kinase A SUR1 Sulfonylurea receptor 1 T2DM Type 2 diabetes mellitus TORCs Transducers of regulated CREB protein activity ZDF Zucker diabetic fatty Author Contributions ''I.A.A