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It is generally considered as the first tier in the therapeutic cascade and patients are monitored by his physician without receiving any active intervention

Metabolite concentrations were normalized to the concentration of water calculated from unsuppressed water spectra, since variations in water content within the sample are expected to be much smaller than the variations in the metabolite level [52]

Ferroptosis, an iron-dependent form of programmed cell death first identified by Dixon et al., is characterized by excessive intracellular iron accumulation, lipid peroxidation and distinct biochemical and morphological features (Dixon et al., 2012)

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