And we do think that European credit might outperform as it's somewhat lagging this animal spirits theme that we think will be led by the U.S
McGuff Pharmaceuticals, Inc dba McGuff Outsourcing Solutions: McGuff operated a 503A compounding pharmacy until the company surrendered their license in response to a complaint by the California Board of Pharmacy in December 2022
Bobby Ghaheris framing) GLP-1 drugs raise circulating GLP levels roughly a thousandfold and produce robust weight loss, though this also comes with muscle loss and sometimes nausea, which is why some people are microdosing them Retatrutide (coming soon from Lily) hits the GLP, GIP, and glucagon systems simultaneously and produces the most robust weight loss of the category while sparing some muscle Growth hormone secretagogues like sermorelin, ipamorelin, and tesamorelin typically produce a three to eightfold increase in growth hormone and IGF-1 but Huberman personally found sermorelin nuked his REM sleep and spiked his PSA for no clear mechanistic reason, and he wasnt impressed with the fat loss results If someone can get a legitimate prescription, real pharmaceutical-grade growth hormone at a low dose (one to two IUs, five nights a week) is a more proven option than unverified secretagogues BPC-157 is a gastric juice-derived amino acid chain with impressive animal data on cartilage regrowth, fibroblast migration, and nerve regrowth, but theres not a single published human trial He personally keeps BPC-157 in the fridge for injury flare-ups but doesnt use it as an everyday recovery tool There are actually a lot of women using peptides like GHK-Cu (copper peptide) in cream or injectable form, not just male gym-goers chasing performance Why no reported side effects is a trap Unlike anabolic steroids in the 80s and 90s, which had well-documented outrageous adverse events (aggression, severe acne, tumors), theres no clearly documented adverse event yet tied to these non-FDA-approved peptides This doesnt mean theyre safe, it likely means adverse events simply arent being reported since theres no formal surveillance system for gray market peptides People seem to feel psychologically safer taking something from the body, even in synthetic form, than taking a more conventional pharmaceutical, even though the actual risk profile isnt necessarily different 01:39:50 AI, Wearables, And The Race To Write To The Nervous System Current AI is only trained on internet data, essentially the output of human neural activity, the real next leap is training AI directly on non-invasively recorded brain activity Wearables like Whoop and Oura only measure heart rate and motion via accelerometers, HRV reflects how much the vagus nerve slows the heart rate, its not a direct readout of the autonomic nervous system itself The real frontier is devices that can both read from and write to the nervous system non-invasively, big AI companies increasingly acquiring biotech companies signals where this is heading Most current commercial vagal stimulation devices are largely ineffective at stimulating the vagus nerve specifically or robustly enough 01:49:32 Inside Andrews New Operating Manual, Protocols Hubermans upcoming book Protocols (out September 15th) is designed around principles rather than rigid rules The resistance training chapter dives into how hypertrophy can be triggered anywhere from 5 to 30 reps as long as you train to failure, though practically doing 30 reps of squats to failure is brutal The light chapter explains that natural sunlight is full spectrum, and getting long-wavelength light (especially early or late in the day) matters for mitochondrial and retinal health without overloading on UV Check our library because this was discussed multiple times already One book chapter also deals with the yearning piece of grief, how the brain circuitry tied to missing someone (or a pet) needs to remap over time The lost person or pet gets reframed in the mind as someone you still have a relationship with, just not an actionable one anymore 01:58:20 Shut Up, Suit Up, Show Up Advice from 86-year-old psychoanalyst Jim Hollis: you have to shut up, suit up, and show up, which sounded like generic advice at first but wasnt One of the better episodes, check it out the notes here Shut up is really about gratitude, somebodys definitely suffering more than you, be grateful for something, youre alive Suit up means preparing yourself mentally to fulfill your roles in life, since drifting from your roles damages self-worth Show up means actually fulfilling those roles once youre prepared This sounds so simple and yet thats hard work, simple is not the same as easy
It is absolutely crucial to work alongside a knowledgeable healthcare provider who deeply understands the nuances of mast cell disorders and can monitor your physiological response
