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Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives

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Amble differentiates by marketing almost exclusively to women and by framing its clinical program around hormonal context, including menstrual-cycle variability and perimenopausal metabolic shifts

The rapid rise of GLP-1 receptor agonists like semaglutide and tirzepatide has transformed obesity and diabetes care, generating billions in revenue for manufacturers Novo Nordisk and Eli Lilly, while creating unprecedented demand for weight management solutions