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Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

Effet anti-inflammatoire et anti-radicaux libres

Mechanism [edit] Glutathione synthase catalyzes the chemical reaction ATP + gamma-L-glutamyl-L-cysteine + glycine ADP + phosphate + glutathione The 3 substrates of this enzyme are ATP, gamma-L-glutamyl-L-cysteine, and glycine, whereas its 3 products are ADP, phosphate, and glutathione

Compounding this, age-associated risk factors such as neurodegenerative changes, ophthalmologic changes reducing light input, sedentary lifestyle, and irregular environmental cues can all contribute to circadian dysregulation in the elderly