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Limitations The doses of EMPA used in the study were based on the clinically tolerable doses of EMPA as an oral hypoglycemic drug

Ketamine as a model of schizophrenia (as acute ketamine administration was associated with schizophrenia-like or psychotomimetic symptoms with large effect sizes, an increase in positive and negative symptoms [275,276]) might escape from the extraordinary complexity of extrapolation from animal models of mental disorders in general [277]

This should be accounted for in research designs that include oral glucose tolerance tests or mixed meal tolerance tests, as retatrutides pharmacodynamic effects will blunt the glycemic response independent of changes in fasting glucose or insulin sensitivity

J Agri Food Chem