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Broadspectrum sunscreen, widebrimmed hats, and shade during peak hours help block UV rays that stimulate melanin production and break down collagen
Some patients may benefit from very low-calorie diets (800 kcal/day) under medical supervision, particularly those with type 2 diabetes or significant obesity-related complications, as outlined in NICE CG189
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Their functional plasticity, shifting between inflammatory, repair, or anti-inflammatory states, depends on metabolic adaptation and lipid remodeling, including choline uptake and phospholipid reorganization ( 2.1.1 Macrophages and dendritic cells Macrophage functions, such as cytokine and chemokine secretion, phagocytosis, and organelle biogenesis, are intricately linked to membrane phospholipid composition, curvature, and charge ( Figure 3 )
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