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Gilead decision, products where the basic patent was subject to an IPR or opposition that narrowed its claims, and products in markets where national courts have shown willingness to depart from the mainstream EU position on SPC validity

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The assays were performed in 96-well plates, and absorbance readings were taken at 500 and 550 nm using a microplate reader

ROS also attack structural and enzymatic proteins via the oxidation of amino acid residues, the formation of transverse bonds and protein aggregates, and proteolysis