what is a known effect of glp-1 Your guide to side effects The promise and peril of

62 The trial demonstrated a dose-dependent reduction in body weight, with the highest dose group (4.5 mg) achieving a 10.8% mean weight loss (11.5 kg), significantly surpassing the placebo group (3.0%, 3.3 kg)

These mechanisms are not fully understood but include central nervous system carbohydrate reduction and glycolysis inhibition, changes in neuronal excitability mediated by ATP-sensitive potassium channels through alterations in mitochondrial function, inhibition of the mammalian target of rapamycin (mTOR) pathway, and inhibition of glutamatergic excitatory synaptic transmission [72]

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& Cotman, C