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What the Data Actually Shows Comprehensive analyses of clinical trial data in 2025 found: No increased risk of suicidal thoughts or behaviors compared to placebo No increased rates of depression among people taking GLP-1 medications Many patients actually reported improved mood and better quality of life Better emotional well-being as patients lost weight and improved their health Why Some People Feel Better on These Medications Many of my Murphy patients report feeling emotionally better once they start weight loss medication, and there are several reasons why: Breaking the cycle of emotional eating: When constant food cravings decrease, people feel more in control Improved self-esteem: Successful weight loss boosts confidence Better physical function: Reduced joint pain and improved mobility enhance quality of life Metabolic improvements: Better blood sugar control and reduced inflammation affect mood regulation Increased energy: Many people feel more energetic as they lose weight Important Individual Note: While the population-level data is reassuring, everyone responds differently to medications

Theranostics 12 , 1999 (2022)

A nationwide aggregated health record analysis

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