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In preclinical models, the GLP-1GIPlanifibranor conjugate improved weight, glycemia, and markers of glucose, liver, and cardiovascular function in mice while using a lanifibranor-equivalent dose approximately 6,900-fold lower than a 30 mg/kg preclinical dose previously required to improve liver metabolism, suggesting improved dosing efficiency and encouraging preclinical safety signals

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Omega-3 fatty acids, especially DHA and EPA, are crucial for brain development and may support improvements in social communication and mood

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