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Cellular iron homeostasis is regulated at the post-transcriptional level through iron-responsive element (IRE)iron regulatory protein (IRP) interactions, which control the translation of mRNAs encoding ferritin, FPN, TfR1, and DMT1.Comprising ferrous iron bound by low-affinity iron chelators, NTBI is a direct consequence of oxidative stress in the circulation and tissue iron loading [30]

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A variety of anticancer drugs based on these principles have been synthesized in efforts to improve their therapeutic indices and reverse tumor resistance

Diabetic patients are also at an increased risk for vascular problems and hypoglycemia, which can contribute to conditions like NAION