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Non-Anti-TNF Biologics and Small Molecules In one of the first real world efficacy studies of vedolizumab in CD, a reduced likelihood of achieving clinical remission after 12 months of vedolizumab was demonstrated in current or former smokers (HR, 0.47
From a regulatory and safety perspective , off-label prescribing requires clear documentation of informed consent, with patients understanding that the medication is being used outside its licensed indications
Am J Public Health 82:10231026
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