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Top discriminatory salivary metabolites included linoelaidic acid, gamma-glutamylcysteine, and 3-hydroxybutyryl-CoA, implicating dysregulated linoleic acid metabolism, redox imbalance, and fatty acid -oxidation in pathogenesis

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The peroxidation of fatty acids in cellular membranes induces a decrease in membrane fluidity and disruption of membrane function and integrity, which is involved in severe pathological changes [9]

Insomnia and sleep disturbances are not listed among the common adverse reactions for tirzepatide in the FDA-approved prescribing information for either Mounjaro or Zepbound