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Sales of these GLP-1 treatments drugs that mimic the effects of blood-sugar-regulating hormone GLP-1, a feature originally intended for diabetes care but which also happened to cause weight loss in test subjects have increased by almost 6x since the start of 2018

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During hypoxia or under certain oncogenic conditions, -ketoglutarate could be converted directly to citrate (following a reversed TCA cycle), in order to generate the cytosolic acetyl-CoA when glucose-derived acetyl-CoA is insufficient [34]

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