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The neuroprotective effects of curcumin are particularly evident in Alzheimers disease, where it addresses multiple pathological features including cholinergic system dysfunction, oxidative damage, and broader nervous system impairment

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IGF-1 is crucial for growth through adolescence, and for cell health and survival throughout life

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This is because it can help repair free radical damage, which causes many age related diseases

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In contrast, SIRT3, SIRT4, and SIRT5 are predominantly present in the mitochondria

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