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SS mitochondria, located beneath the sarcolemma, are more susceptible to early oxidative damage, whereas IMF mitochondria, with higher oxidative capacity, become increasingly sensitive to apoptotic signals during injury (Ji and Yeo, 2019)

This process can accelerate after 50 due to: Hormonal changes Lower activity levels Reduced protein intake Slower recovery Why Muscle Matters (More Than the Scale) Muscle is about much more than appearance

The cross talk between these two cascades is mediated by cytokines, vascular endothelial growth factor (VEGF), and ROS (both reactive nitrogen and oxygen radicals)

Stage 3 is when you are diagnosed