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In a lithium-pilocarpine model of epilepsy GLP-1RA liraglutide modulated inflammation, reduced oxidative stress, and triggered antioxidant pathways in rats with induced epileptic status, as well as improved mitochondrial function in both healthy rodents and rats with epileptic status

The question of co-administration safety arises frequently in telehealth consultations

Large randomized trials including the LEADER, SUSTAIN, STEP, and SURMOUNT studies monitored thousands of patients and found that moderate heart rate increases during GLP-1 therapy did not increase the risk of heart attacks or strokes

The only significant change was a 6% decrease in platelet count (p = 0.02)