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Some of the positive effects that vitamin B12 has on semen quality and sperm physiology: It works in ways to increase the sperm count, enhancing sperm motility, and reducing sperm DNA damages

Investigating these strategies in an animal model (such as an orthotopic humanized mouse model of GBM) will be an important next step to bring this targeting strategy to clinical fruition

The combination may reduce gut inflammation on multiple levels, including systemically, via cytokine signaling, and through modulation of the intestinal immune response

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