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Instead, it functions as a neuromodulator, altering the baseline activity of multiple systems to favor a state of rest and homeostasis

Estradiol and the development of the cerebral cortex: an unexpected role

Mnzel T, Keaney Jr JF

This is consistent, the team said, with the prevailing hypothesis suggesting that [semaglutides] therapeutic effects arise from overlapping neurobiological mechanisms that modulate both metabolic regulation and reward-related pathways shared between obesity and alcohol use disorder. The team concluded: Findings from this trial provide support for broadening the indication for semaglutide to [include] AUD in patients with a BMI of 30 or greater, which could benefit millions. About 890 million adults globally have a BMI over 30, and in the U.S., 8 million adults are estimated to have obesity and high alcohol consumption