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Yes you heard right you can smoke 500 Cigarettes at once

The Nicotine vaping in England: 2022 evidence update, a report led by academics at Kings College London with a group of international collaborators, reviewed international evidence to find that vaping poses a small fraction of the risks of smoking, in the short and medium term, stating that vaping is at least 95% less harmful than smoking

If you want to learn more about the 1964 Surgeon Generals report, including original pages and scans of articles that followed, I recommend this resource from the University of Alabama

These chemicals include the neurotransmitter dopamine, which at higher doses can cause a pleasant sensation (hence its use as an antidepressant)