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Although this study showed no cytotoxic effects of the analogues on cells at the highest concentration (3.25 mmol/L), or any visible adverse effects on rats at near the maximum equivalent human dose for GSH (1000 mg/kg), it is worth noting that the long-term effects and analysis of the effects of the analogues metabolites were beyond the scope of this study

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Notably, a recent study demonstrated that gut microbiota-derived serotonin directly signals to intestinal T cells, promoting Treg differentiation during neonatal development [249]