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Harm Reduction Prevails Anyway Despite the pessimistic bias of including dual-use in the EC switchers group, they actually did have favorable health outcomes compared to the exclusive smoking group, demonstrating harm-reduction: Paper 1 (COPD) found that those using ECs after 1 year had significantly lower odds of MACCE after 5 years (adjusted hazard rate (AHR) = 0.80) which was a similar reduction in risk found in those who quit all nicotine (AHR = 0.85)

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Acknowledgements Research program of VD-G is supported by the FRM grant DPA20140629795, the EquipEx grant OptoPath (ANR-10-EQX-008-1), by INSERM, the University of Bordeaux, and the Aquitaine Region Council