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doi: 10.3389/fphar.2025.1697192 Received 01 September 2025 Revised 24 November 2025 Accepted 30 November 2025 Published 05 January 2026 Volume 16 - 2025 Edited by Silvia Barbon, University of Padua, Italy Reviewed by Girish Pattappa, University of Wurzburg, Germany Malay K

For instance, PPR significantly alters the pharmacokinetics of carbamazepine, increasing its maximum plasma concentration, half-life, and area under the curve by 68.7, 47.9, and 43.2%, respectivelyelevating risks of drug toxicity (85)