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Autosomal dominant disorder caused by mutations that affect the red cell membrane skeleton, leading to loss of membrane and eventual conversion of red cells to spherocytes, which are phagocytosed and removed in the spleen Manifested by anemia and splenomegaly Autosomal codominant disorders caused by mutations in - or -globin that reduce hemoglobin synthesis, resulting in a microcytic, hypochromic anemia

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Skin develops a firmer texture with improved elasticity

The role of the central ghrelin system in reward from food and chemical drugs