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Mounjaro (tirzepatide) has produced the highest average weight loss in randomised controlled trials and may be suitable where maximum effectiveness is the priority Wegovy (semaglutide) is a well-evidenced, widely available alternative with a strong safety record and a slightly longer history of real-world use Saxenda and Ozempic have more limited roles in weight management but remain appropriate for specific patients The right treatment is the one that fits your medical circumstances, is accessible to you in the UK, and that you can sustain over the long term

8 Similarly, an analysis of National Health and Nutrition Examination Survey data from 2017 to 2020 found that only 4.4% of US adults with type 2 diabetes used GLP-1 RAs

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However, there is substantial variation in break-even costs among firms, with many operators able to profitably drill new wells with the price of WTI as low as $45 per barrel ( Chart 2 )