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It mediates the local inflammatory response through the synthesis of prostaglandins, which affect atrial function and morphology ( In summary, COX-2 has a major impact on the pathogenesis of myocardial ischemia through its involvement in inflammation, cardiac remodeling, and apoptosis, highlighting its potential as a therapeutic target to mitigate disease progression ( 2.3.4.2 Endothelin-1 (ET-1) ET-1 is a potent vasoconstrictor with important effects on the heart and blood vessels

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