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Muscle cramps during GLP-1 therapy are typically caused by indirect factors including electrolyte depletion (especially magnesium and potassium) from gastrointestinal side effects, dehydration from reduced fluid intake or vomiting/diarrhea, rapid weight loss with some lean mass reduction, and increased physical activity exceeding current conditioning levels

The glutathione status of cells

Imaging substudies have shown that visceral adipose tissue can decrease as part of this overall weight loss, though the proportion varies between individuals

Dosing errors have resulted from patients measuring and self-administering incorrect doses of the drug and health care providers miscalculating doses of the drug, the FDA alert said