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Systemic IL-33 produced by keratinocytes synergizes with intestinal IL-25 to drive the expansion and activation of intestinal Type 2 innate lymphoid cells (ILC2s) that produces IL-4 and IL-13, which increases the number of mucosal MCs in the intestine ( Dysbiosis of Intestinal Microbiota and Systemic Disorders Intestinal microbiota exerts the key roles in the physiology of human being, and chronic cigarette smoking as an environmental factor induces dysbiosis of intestinal microbiota (Tremlett et al., 2016), and autoimmune disorders (Figure 3)

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doi:10.1007/s12020-011-9559-x

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