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Mitochondria are central regulators of energy production and play pivotal roles in the cellular stress response and induction of apoptosis, and thus it is logical to propose that mitochondrial dysfunction may be a causative factor in energy imbalance and a key player in disease progression in various lung diseases

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Cigarette smoke contains numerous harmful chemicals, including nicotine, tar, carbon monoxide, and carcinogens, which can have severe negative effects on the body

A study of tobacco and hazardous or harmful alcohol use in 39,290 participants from Thailand in 2004 found the strongest predictor of harmful or hazardous alcohol consumption was smoking and the strongest predictor of smoking was harmful or hazardous alcohol use in both men and women[24]