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Despite this small heart rate effect, large-scale cardiovascular outcome trials, including the SUSTAIN-6 study, have demonstrated that semaglutide is associated with cardiovascular benefits in people with type 2 diabetes at high cardiovascular risk

This interrupts negative feedback signaling in the pituitary gland of the brain, resulting in increased release of the ovary-activating hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH)

Shock and Critical Care: Supports treatment in adrenal insufficiency, septic shock, and other life-threatening conditions requiring corticosteroid intervention

Muscle loss The average weight loss in one clinical trial with Wegovy was 15% in 68 weeks, a significant reduction