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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability
The use of MOTs-C as a companion to GLP-1s, to prevent muscle loss, might get around this shortcoming of GLP-1s, but rigorous research is needed to prove [its effectiveness]
Those requiring supplementationsuch as vegans, individuals with pernicious anaemia, or those with malabsorption conditionsshould follow guidance from their GP or registered dietitian to ensure appropriate dosing
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