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Although technically two copies of both genes (homozygous) would be worse, it is very uncommon, whereas the heterozygous C677T/1298C is much more commonly the worst case scenario I have double gene mutation homozygous hereditary hemochromatosis I have SEVERE CFS SEVERE FIBRO DEPRESSION ANXIETY BIPOLAR SEVERE MCS

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In conclusion, when using ICG for surgical navigation of HCC, surgeons need to consider the above factors and combine them with other imaging modalities and clinical findings to ensure the accuracy and safety of surgical navigation