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In particular, histone deacetylases (HDAC) are potential therapeutic targets in different neurological conditions (Grff and Tsai, Another mechanism of epigenetic regulation is mediated by microRNAs, which cause the degradation of genes involved in the development and progression of BBB dysfunction (Figure 2) (Ma et al., Figure 2)

We used the GEO accession number GSE178265 to download single-cell data in the GEO database ( Annotated information of cell types was also downloaded from the Broad Institutes Single Cell Portal ( PD-related bulk RNA-seq data (GSE49036, GSE20164) was downloaded and viewed in the GEO database

Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease, and drug therapy

But like any powerful medication, it demands thoughtful prescribing, patient education, and careful monitoring