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additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable

Receptor KISS1R (GPR54) Position in HPG axis Upstream of GnRH Clinical lead form Kisspeptin-54 KPV Research Dossier A structured evidence dossier on KPV (Lys-Pro-Val), the anti-inflammatory C-terminal tripeptide of alpha-MSH

Diabetologia 55 , 24452455 (2012)

Figure 3 5 The double-edged sword: antiretroviral therapy and mtDNA Antiretroviral therapy (ART) represents one of the most successful medical interventions in modern history, transforming HIV infection from a fatal diagnosis into a manageable chronic condition