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In the early twentieth century, cigarette manufacturers developed new blends using American-grown tobacco, such as sugared burley tobaccos (Giovino 2002)
In their analysis, the study authors raised the need for direct comparisons focusing on the harm and tolerability of the four most effective treatment options e-cigarettes, varenicline, bupropion and combination NRT to aid clinical decision-making
I imagine that would be a tough changeover since everyone expects them and would say "what the crap" if they shipped with anything else
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