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Long-term safety data spans several years across multiple populations

[DOI] [PubMed] [Google Scholar] Pappas TN, Welton M, Debas HT, Rivier J, Tach Y

Analogues 1 and 2 exhibited superior potency (IC 50 = 0.30 and 0.94 M, respectively), up to 90 times more selective for AKR1C3 over AKR1C2, and demonstrated higher efficacy than indomethacin without off-target effects on AKR1C2 and COX1/2 ( 6.1.3 N-phenylanthranilic acids Among the compounds explored as AKR1C3 inhibitors, Flufenamic acid (FLU), a sort of NSAIDs, has demonstrated potent inhibition of AKR1C3 activity (IC 50 = 8.63 M)

Both of these amino acids are found in significant amounts in all animal protein sources, such as meat, milk and its derivatives, and fish