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In a murine model of renal cell carcinoma, upregulation of G6PD and subsequent increase in NADPH was found to inhibit ferroptosis whereas G6PD knockdown in human hepatocellular carcinoma cells increased positive regulators of ferroptosis 83,84,85

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396 Metabolic disorders Overnutrition is a driving factor for obesity and related metabolic disorders, mainly including type 2 diabetes mellitus (T2DM), metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), and polycystic ovarian syndrome (PCOS)

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