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The mixture was then cooled to 0 C, and a toluene-dichloromethane mixture (v/v, 3:1) solution containing 0.8 g of SAC was added dropwise

In preclinical studies, the drug has shown strong anti-tumor activity and survival advantage in AML, DLBCL, cALL, and Burkitt lymphoma tumor models

36 If patients are already close to their glycaemic target before starting GLP-1RAs, the dose of their other antihyperglycaemic medications, especially insulin and sulfonylureas, may need to be decreased at GLP-1RA prescription, to prevent hypoglycaemia

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