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The dopamine-transporter SPECT substudy embedded in Exenatide-PD3 showed no separation between exenatide and placebo, mirroring the null clinical result and offering no imaging signal of preserved nigrostriatal terminals [2]

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In addition, fetal congenital abnormalities in animal models of GLP1RA use in pregnancy are reported by both Eli Lilly and Novo Nordisk in the prescribing information for Mounjaro (tirzepatide, a dual Glucose-dependent insulinotropic polypeptide [GIP] and GLP1R agonist

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