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Within the TCA cycle, succinate is converted into fumarate by the succinate dehydrogenase (SDH) which represents the respiratory ETC complex II (CII) 73 (Supplementary Fig

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However, these positive benefits in animal studies have apparently not been translated into likely beneficial clinical outcomes

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Citation on PubMed El-Hattab AW, Li FY, Shen J, Powell BR, Bawle EV, Adams DJ, Wahl E, Kobori JA, Graham B, Scaglia F, Wong LJ

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10.1074/jbc.275.7.4613 96 LyapinaS.CopeG.ShevchenkoA.SerinoG.TsugeT.ZhouC.et al (2001)

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