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This compound targets the NNMT enzyme involved in fat cell metabolism without overlapping with AOD-9604 mechanisms

Boohaker RJ, Sambandam V, Segura I, Miller J, Suto M, Xu B

Absolute contraindications include personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), previous serious hypersensitivity to semaglutide or formulation components, pregnancy (the medication should be discontinued at least 2 months before planned conception), and breastfeeding due to insufficient data on excretion in human milk