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This leads to NF-B-mediated expression of pro-inflammatory cytokines (IL-6 and TNF-), constituting a core mechanism of acute gout attacks

471 Knocking down FTH in cardiomyocytes prevents free iron from being stored in ferritin, increases unstable iron pools, promotes intracellular ROS production, activates oxidative stress, and causes ferroptosis in cardiomyocytes, leading to age-related heart damage

For children aged 13 years, the recommendation increases to 0.5 mcg per day , then to 0.8 mcg per day for ages 46 years, and 1.0 mcg per day for ages 710 years

Calcium oxalate crystals and oxalate induce an epithelial-to-mesenchymal transition in the proximal tubular epithelial cells: contribution to oxalate kidney injury