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An analysis of differential regulation of SMA2 gene by silencing of individual HDAC isoforms by shRNA identified HDAC 2 and 6 as potential regulators of SMA 2 expression (Evans et al., 2011) Screening of a library of cyclic peptide inhibitors of HDAC on a neuronal cell line derived from a SMA patient's induced pluripotent stem cells identified HDAC inhibitors, which induced the expression of SMA2 (Lai et al., 2017)

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