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Quinolinic acid (QUIN), a Kyn metabolite and an N-methyl-D-aspartate (NMDA) receptor agonist, enhances glutamate excitotoxicity, promotes epileptiform discharges, and aggravates depressive behaviors

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In particular, the 55 most highly expressed genes in the invasive MC58 strain included genes encoding proteins involved in amino acid transport and metabolism ( argH , aroA , aroB , ilvC , and gdhA ), genes for ATP synthase subunits ( atpA , atpD , atpG ), genes involved in sialic acid capsule biosynthesis ( siaB , siaC ), and an operon encoding Na + -translocating NADH-quinone reductase subunits ( nqrB , nqrC , nqrD )