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The EDICT study, employing diabetes medications (GLP-1 receptor agonist, pioglitazone, metformin) that correct the basic underlying pathophysiologic defects present in type 2 diabetes, convincingly demonstrated that combination therapy produces a greater and more durable reduction in HbA1c than the treat-to-fail approach using diabetes medications (sulfonylureas, metformin, insulin) that do not correct the basic metabolic and cellular defects (insulin resistance and beta-cell dysfunction) present in type 2 diabetes patients

(PubMed) Levander OA, Whanger PD

While NAD+ and glutathione supplements are generally well-tolerated, some individuals may experience minor side effects, such as nausea, headache, or flushing during NAD+ infusionthese typically resolve by slowing the infusion rate

Modern science is now beginning to unravel the specific compounds and mechanisms that might explain these observations