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Of note, the ageing lung shows morphological changes that resemble emphysema in COPD, including alveolar enlargement and a reduction in elastic recoil, contributing to lung function decline [42]

In both THP1 cells and primary human peripheral blood macrophages, the half-life of NLRP3 was slightly longer (~ 56 h in an unchallenged condition) than in U937 cells (~ 4 h in an unchallenged condition) [6]

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